![]() Epilepsia 55:e18–e21ĭel Felice A, Beghi E, Boero G, La Neve A, Bogliun G, De Palo A, Specchio LM (2010) Early versus late remission in a cohort of patients with newly diagnosed epilepsy. Epilepsy Res 151:24–30Ĭhild ND, Stead M, Wirrell EC, Nickels KC, Wetjen NM, Lee KH, Klassen BT (2014) Chronic subthreshold subdural cortical stimulation for the treatment of focal epilepsy originating from eloquent cortex. Neurology 84:810–817Ĭhang CW, Lee ST, Lim SN, Cheng MY, Lee CY, Wu T (2019) Electrical cortical stimulation for refractory focal epilepsy: a long-term follow-up study. Our report confirms that electrical cortical stimulation with detailed implantation procedures is safe and effective for patients with drug-resistant epilepsy originating from eloquent cortex.īergey GK, Morrell MJ, Mizrahi EM, Goldman A, King-Stephens D, Nair D, Srinivasan S, Jobst B, Gross RE, Shields DC, Barkley G, Salanova V, Olejniczak P, Cole A, Cash SS, Noe K, Wharen R, Worrell G, Murro AM, Edwards J, Duchowny M, Spencer D, Smith M, Geller E, Gwinn R, Skidmore C, Eisenschenk S, Berg M, Heck C, Van Ness P, Fountain N, Rutecki P, Massey A, O'Donovan C, Labar D, Duckrow RB, Hirsch LJ, Courtney T, Sun FT, Seale CG (2015) Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Pre-surgical planning enhanced the accuracy of electrode placement and led to a favorable seizure reduction rate. Comparisons of their seizure frequency at baseline and during the postoperative period revealed a mean reduction in seizures of 60.4% at the first year and 65.6% at the second year. The mean age of these patients was 21.1 years old and the average post-operative follow-up was 77.3 months. ResultsĮight patients received chronic cortical stimulation implantations between February 2003 and December 2017. Patients were discharged and followed up regularly for parameters adjustment and recording of seizure outcomes. Bipolar cyclic stimulation and post-implantation VEEG were performed for 7 days. Post-operative 3D CT ensured the accurate location of stimulation lead without any misplacement. A final quadripolar lead in cyclic stimulation mode was then placed and secured on the target cortex area. The localization of the grid was determined via 3D reconstruction imaging of subdural electrodes co-registered onto the patient’s cortex. ![]() To confirm the precision of subdural grids covering the epileptogenic foci in the eloquent regions, pre- and intra-operative video-electroencephalography (VEEG) were performed in patients with drug-resistant epilepsy during a 4-day 24-h monitoring. ![]() We demonstrated how detailed procedures of pre- and intra-operative planning of cortical stimulation implantation may influence the results of seizure reduction rate. ![]() Electrical cortical stimulation is shown effective in treating patients with drug-resistant epilepsy. ![]()
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